PGD - Embryo Genetics

PGD - Embryo Genetics

Preimplantation genetic diagnostics is a method which allows to uncover some genetic abnormalities in the genetic embryo structure before their transfer into uterus.

Changes in chromosome count, their structure or some types of hereditary diseases are being tested. The PGD is possible to use only in the relation with IVF cycle – after 72 hours of its development, 1-2 cells are taken from the embryo (blastomeres) which don’t have any specialization yet and the embryo doesn’t miss them. These cells are subjected to genetic testing. Clinical studies doesn’t prove negative influence of further embryo development.

This method improves the chance of successful pregnancy by excluding proven defected embryos and by using embryos genetically healthy in evaluated parameters.

The PGD method is recommended to couples when:

  • Woman’s age is higher than 35 year which increases the probability of giving birth to a baby with abnormal chromosome count (e.g. Down’s syndrome)
  • There’s already been a miscarriage or birth of fetus with chromosome disorder
  • There are recurrent failures in IVF treatment or recurrent miscarriage in early stage of pregnancy
  • One partner was cytogenetically found with chromosome redevelopment. Even though this individual is not handicapped, this redevelopment can lead to creating of genetically abnormal oocytes or sperm which could transfer the disorder to descendants.
  • There is disorder in the family bound to sex (the disorder handicaps only men but genetically is transmitted by women).
  • One of partners is undergoing or have been subjected to chemotherapy or radiotherapy.
  • For oocyte fertilization in the IVF cycle has been used partner’s sperm with non-obstructive form of azoosperm collected by MESA or TESE methods.

Embryos without genetic disorders are transferred into woman’s uterus.

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